Publications
Vijan A, Thai C, Jenkins J, Chandler P, Chen C. A Phase 1, Randomized, Placebo-Controlled, Double-Blind, 2-Period, Fixed-Sequence Study to Assess the Relative Bioavailability and Safety of Low-Sodium Oxybate Between Japanese and Non-Asian Participants. American College of Clinical Pharmacology (ACCP 2023). August 2023 doi.org/10.1002/cpdd.1299
Wray L, Berwaerts J, Critchley D, Hyland K, Chen C, Thai C, Tayo B. Pharmacokinetic Drug-Drug Interaction with Coadministration of Cannabidiol (CBD) and Everolimus in a Phase 1 Healthy Volunteer Trial. Clinical Pharmacology in Drug Development. 2023 May. doi.org/10.1002/cpdd.1262
Ohta Y, Ichiro Y, Yamamoto H, Chen C, Thai C, Yamazaki F, Nortvedt C, Matsumoto N. Study on pharmacokinetics, safety and tolerability of cannabis-derived cannabidiol (CBD). The 43rd Annual Scientific Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics. 2022 Nov. doi.org/10.50993/jsptsuppl.43.0_1-C-O04-7
Matsumoto N, Ohta Y, Yamamoto H, Takumi I, Yamazaki F, Thai C. Pharmacokinetics, safety, and tolerability of cannabidiol (GWP42003-P) as a SAD and MAD in Japanese and white subjects. Epilepsy Research (Journal of the Japan Epilepsy Society) 2022 Aug; 40(2): 477 jglobal.jst.go.jp/public/202202240664492697
Hayes A, Mok NY, Liu M, Thai C, Henley AT, Atrash B, Lanigan RM, Sejberg J, Le Bihan YV, Bavetsias V, Blagg J, Raynaud FI. Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution. Xenobiotica. 2017 Sep;47(9):771-777. doi.org/10.1080/00498254.2016.1230245
Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Müller S, van Montfort RL, Brennan PE, Blagg J. 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1388-409. doi.org/10.1021/acs.jmedchem.5b01635
Mallinger A, Schiemann K, Rink C, Stieber F, Calderini M, Crumpler S, Stubbs M, Adeniji-Popoola O, Poeschke O, Busch M, Czodrowski P, Musil D, Schwarz D, Ortiz-Ruiz MJ, Schneider R, Thai C, Valenti M, de Haven Brandon A, Burke R, Workman P, Dale T, Wienke D, Clarke PA, Esdar C, Raynaud FI, Eccles SA, Rohdich F, Blagg J. Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J Med Chem. 2016 Feb 11;59(3):1078-101. doi.org/10.1021/acs.jmedchem.5b01685
Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J Med Chem. 2015 Feb 26;58(4):1717-35. doi.org/10.1021/jm501436m